Thursday, March 20, 2014

The Development of PT-141

PT-141 was developed from the Melanotan 2 Peptide, which underwent testing as a sunless tanning agent. In initial testing, Melanotan 2 did induce tanning, but additionally caused sexual arousal and spontaneous erections as unexpected side effects in nine out of the ten original male volunteer test subjects. Palatin completed patient treatment in its Phase 2B clinical trial in premenopausal women with FSD Primary data analysis and announcement of top-line results anticipated in first-half of fourth quarter of calendar year 2012. In studies, PT-141 was shown to be effective in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). Unlike Viagra and other related medications, it does not act upon the vascular system, but directly increases sexual desire via the nervous system.

PT-141 and Sexual Dysfunction

PT-141 is a potential remedy for the treatment of sexual dysfunction; specifically, male erectile dysfunction. Studies have shown that PT-141 does not act on the vascular system like former compounds, but allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation. PT-141 is a melanocortin based peptide that has shown effectiveness in clinical studies on both male and female rats. Male rats have shown erectile response with doses as low as 1-2 mgs whereas most female rats have shown positive results with higher doses around 2-3 mgs. While the dosage requirements tend to be higher for female rats, the observable results in female rats tend to be stronger.


PT-141 Bremelanotide 

PT-141 Peptide
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Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Molecular formula: C50H68N14O10
Molar Mass: 1025.2
CAS number: 189691-06-3
PubChem: CID 9941379
PT-141 Structural Names: cyclo-[Nle4, Asp5, D-Phe7, Lys10]alpha-MSH-(4-10)
PT-141 is a metabolite of Melanotan 2

Buy PT-141 (Bremelanotide) | Peptide Sciences

PT-141 or Bremelanotide is the generic term for a research peptide being studied for its possible use in helping to improve sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). PT-141 was developed from the tanning peptide Melanotan 2, which is a synthetically produced variant of a peptide hormone naturally produced in the body that stimulates melanogenesis that is known as alpha-Melanocyte stimulating hormone. MSH, activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido. Resultantly, PT-141 has been shown in studies to exhibit libido-enhancing effects by activating the melanocortin receptors MC1R and MC4R, but not skin tanning. Melanotan 1 and Melanotan 2 have been researched for their use in protecting against the harmful effects of ultraviolet radiation from sunlight due to their

Bremelanotide PT141 peptide

Bremelanotide
Bremelanotide PT141 10mg*10vial/kit
Bremelanotide PT141 is a research peptide developed by United States. PT-141 functions by activating the melanocortin 1 receptor and MC4R namely. Bremelanotide originally was tested for nasal spray delivery but was discontinued after concerns about side effects. Bremelanotide PT141, as Melanotan II, may cause spontaneous arousal enhancing effect. Unlike other supplements, pt 141 results do not act on the vascular body, but directly increases desires through the nervous system.
Bremelanotide PT-141 Peptide Synthesis Information

Our PT141 delivers 99% purity ratings, HPLC quality tested PT-141 10MG. PT141 USA Company ensures good experience offering 2 day average guarantee order process times. Bremelanotide vials deliver on label claims and remains preserved when reconstituted with bac water for injection. Furthermore, bremelanotide triggers the melanocortin system to cascade variably to melanocortin receptors, more than PDE5 meds. Small-structure biologic melanocortin peptides molecule remains potent during shipping as well as in storage. Melanotan 2 and PT141 melanocortins do not require cold shipping to remain effective. Products stay potent and should not expire until years later when stored properly in the fridge or freezer.

PT-141 is a synthetic amino acid protein discovered during clinical trials using the Melanotan 2 for sunless tanning, photo-protection results from melanotans. Participants were documented as having experienced aphrodisiac reactions, leading to the further development of Bremelanotide PT-141. The melanocortin system targets receptors associated with desire through the melanocyte stimulating hormone paths that cross the blood-brain-barrier. Potentially the powerful sex-drug results feeling an aphrodisiac experience amplifying arousal pt141 reviews have shown the ability to increase libido effects of both men and women.

We offers low prices on quality melanocortin agonist worldwide. Synthetic libido amino acid Bremelanotide PT-141 and Melanotan 2 are potent aphrodisiac discovered during test of sunless tanning melanotan results. Reliable clinical study requires consistent proteins for accurate laboratory research, skin type variations is a challenge for developing legit pt-141 instruction guide. Melanotan USA information on premium melanocortin reagents made filler-free, buy bremelanotide pt-141 peptide direct from United States Company. Custom bac water and bacteriostatic sodium chloride .9% USP for injection reconstitute amino peptide MT2, PT141 cyclic analogs best research.

Bremelanotide PT-141 Instruction

Bremelanotide PT-141 Instruction
Bremelanotide PT 141 Dosage:
Light: .5mg
 Common: 1mg
 Large: 2mg
Trusted Supplier: PT-141
Bremelanotide PT-141 was developed from Melanotan 2 (MT-II). PT-141 is a metabolite of melanocyte stimulating hormone that targets desire.
PT-141 bremelanotide molecule research chemical
Treatment:  PT-141 is the only synthetic aphrodisiac. The aphrodisiac effects of Bremelanotide are in a class of its own. Studies have shown Bremelanotide to be effective in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). Nine out of ten volunteers experienced sexual arousal in clinical trials. Unlike Viagra and other related medications (PDE5s - blood pushers), PT-141 acts upon the nervous system. Viagra, Cialis and Levitra are not considered aphrodisiacs as they do not have any direct effect on the libido. However, treatment with PDE5 inhibitors and PT-141 have known synergy.
 Men's Journal Magazine: ...it took hold. I felt a great surge of affection (greater than any regular level of arousal). My body tingled and I developed an erection that wouldn’t quit. For two hours the drug wouldn’t let me out of its grasp — nor my wife out of mine.
Men's Journal PT-141
Females: Women who took part in trials said that they felt a "tingling and a throbbing" along with "a strong desire to have sex." An initial flush occurs post injection, followed by nausea which is dose dependent. For most, effects generally do not take place until a couple hours post injection, peaking around the four hour mark. Men said PT-141 made them feel "younger and more energetic" as well as sexually interested and aroused. "You're ready to take your pants off and go," said user "a product that makes you not only able to but eager to."

Window of Opportunity: Bremelanotide, injected (subcutaneously), has a unique window of opportunity lasting six to 72 hours. In lab trials female rats exposed to PT-141 began "flirting" with male rats for sex. Postures and movements left no doubt in the male rats minds that they were in the mood. The human PT-141 date is one where the dosage precedes the activity by at least a couple hours. When the stars align, hours after the injection, ...this is your window of opportunity, enjoy. 
Bremelanotide PT141 Peptide: Bremelanotide sold online comes in 10mg vials. As a lifestyle melanocortin research peptide, the 10mg product is a lot to consume and may offer up to 20+ doses when dosing PT-141 conservatively. Quality PT141 reconstituted with bacteriostatic water remains potent and preserved for months.
Mixing PT-141: Bacteriostatic water is used for reconstitution.
Example- 1ml(cc) bacteriostatic water per 10mg PT-141 vial equates to a 1mg dose approximately each 10 units on a U100 insulin syringe.
 Example- 1ml(cc) bacteriostatic water per 2mg PT-141 vial equates to a 1mg dose approximately every 50 units on a U100 insulin syringe.
Recommended strategy for mixing and dosing would be to reconstitute with the volume that yields a .1ml injection.
Example- 1ml(cc) bacteriostatic water per 10mg PT-141 vial equates to a 1mg dose approximately each 10 units on a U100 insulin syringe.
 Example- .2ml(cc) bacteriostatic water per 2mg PT-141 vial equates to a 1mg dose approximately every 10 units on a U100 insulin syringe.
PT141 Dosing: Read as much as possible to gain clarity and align expectations. Gradually dosing melanotan peptides increases likelihood for success without sides (desensitization occurs rapidly). Test PT-141 dosage of .25-.5mg on first attempt is recommended. 1mg, give or take a quarter, is the efficacious dose yielding most positive reports.

PT141 (Bremelanotide) 10mg Vials

pt-141
PT141 is a melanocortin agent that can be used to stimulate the central nervous system in animals without having to directly affect the vascular system. Researchers hope to better determine proper levels of administration for this chemical so it can one day replace products such as Cialis, Viagra or other phosphodiesterase-5 inhibitors (PDE-5 inhibitors) that are known to exhibit potentially dangerous side effects.
Unlike PDE-5 inhibitors, PT141 has not yet been approved for use in men or women. Ongoing studies are comparing the effects of both classes of chemicals on a variety of animal subjects to better understand their effects on different organ and tissue symptoms. There is not yet an approved dosing that is considered safe for use.